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Kevin Downard Mass Spectrometry of Protein Interactions


The authoritative guide to analyzing protein interactions by mass spectrometry Mass spectrometry (MS) is playing an increasingly important role in the study of protein interactions. Mass Spectrometry of Protein Interactionspresents timely and definitive discussions of the diverse range of approaches for studying protein interactions by mass spectrometry with an extensive set of references to the primary literature. Each chapter is written by authors or teams of authors who are international authorities in their fields. This leading reference text: * Discusses the direct detection of protein interactions through electrospray ionization (ESI-MS); ion mobility analysis; and matrix-assisted laser desorption/ionization (MALDI-MS) * Covers the indirect analysis of protein interactions through hydrogen-deuterium exchange (HX-MS); limited proteolysis; cross-linking; and radial probe (RP-MS) * Guides researchers in the use of mass spectrometry in structural biology, biochemistry, and protein science to map and define the huge number and diversity of protein interactions * Reviews the latest discoveries and applications and addresses new and ongoing challenges This is a comprehensive reference for researchers in academia and industry engaged in studies of protein interactions and an excellent text for graduate and postgraduate students.

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Группа авторов Protein Interactions


The interactions of proteins with other molecules are important in many cellular activities. Investigations have been carried out to understand the recognition mechanism, identify the binding sites, analyze the the binding affinity of complexes, and study the influence of mutations on diseases. Protein interactions are also crucial in structure-based drug design. This book covers computational analysis of protein-protein, protein-nucleic acid and protein-ligand interactions and their applications. It provides up-to-date information and the latest developments from experts in the field, using illustrations to explain the key concepts and applications. This volume can serve as a single source on comparative studies of proteins interacting with proteins/DNAs/RNAs/carbohydrates and small molecules. Contents: Protein–Protein Interactions: Structural and Dynamical Aspects of Evolutionarily Conserved Protein–Protein Complexes (Himani Tandon, Sneha Vishwanath and Narayanaswamy Srinivasan) A Comprehensive Overview of Sequence-Based Protein-Binding Residue Predictions for Structured and Disordered Regions (Amita Barik and Lukasz Kurgan) Prediction of Protein–Protein Complex Structures by Docking (Danial Pourjafar-Dehkordi and Martin Zacharias) Binding Affinity of Protein–Protein Complexes: Experimental Techniques, Databases and Computational Methods (M Michael Gromiha) Mutational Effects on Protein–Protein Interactions (Jackson Weako, Attila Gursoy and Ozlem Keskin) Predicting the Consequences of Mutations (Hemant Kumar and Julia M Shifman) Protein–Nucleic Acid Interactions: Computational Approaches for Understanding the Recognition Mechanism of Protein–Nucleic Acid Complexes (Ambuj Srivastava, Dhanusha Yesudhas, A Kulandaisamy, Nisha Muralidharan, C Ramakrishnan, R Nagarajan and M Michael Gromiha) Prediction of Nucleic Acid Binding Proteins and Their Binding Sites (Dhanusha Yesudhas, Ambuj Srivastava, Nisha Muralidharan, A Kulandaisamy, R Nagarajan and M Michael Gromiha) Predicting Protein–Binding Sites in Nucleic Acids (Kyungsook Han) Docking Algorithms and Scoring Functions (Arina Afanasyeva, Chioko Nagao and Kenji Mizuguchi) Recent Progress of Methodology Development for Protein–RNA Docking (Yun Guo, Xiaoyong Pan and Hong-Bin Shen) Protein–Ligand Interactions: Protein–Carbohydrate Complexes: Binding Site Analysis, Prediction, Binding Affinity and Molecular Dynamics Simulations (K Veluraja, N R Siva Shanmugam, J Jino Blessy, R A Jeyaram, B Lalithamaheswari and M Michael Gromiha) Quantitative Structure-Activity Relationship in Ligand-Based Drug Design: Concepts and Applications (Vishnupriya Kanakaveti, P Anoosha, R Sakthivel, S K Rayala and M Michael Gromiha) Protein–Ligand Interactions in Molecular Modeling and Structure-Based Drug Design (Devadasan Velmurugan, Dasararaju Gayathri, Chandrasekaran Ramakrishnan and Atanu Bhattacharjee) An Overview of Protein–Ligand Docking and Scoring Algorithms (Ruchika Bhat, Abhilash Jayaraj, Anjali Soni and B Jayaram) Readership: Graduate students and researchers working on protein interactions; researchers in the fields of bioinformatics, computational biology, computational chemistry, biochemistry, biophysics.Protein Interactions;Binding Sites;Prediction;Structural Analysis;Recognition Mechanism;Computational Methods;Protein-protein;Protein-RNA;Protein-DNA;Protein-ligand;Binding Affinity;Mutation;Databases;Web Servers;QSAR;Docking;Molecular Dynamics;Drug Design0 Key Features: Single unique source with concepts and applications on all types of protein complexesWritten by outstanding researchers in the field with easily understandable illustrationsCompilation of databases and online toolsUp-to-date literature and latest developments

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Hugo Kubinyi Proteomics in Drug Research


From skillful handling of the wide range of technologies to successful applications in drug discovery – this handbook has all the information professional proteomics users need. Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field. Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics. Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.

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Группа авторов Prediction of Protein Structures, Functions, and Interactions


The growing flood of new experimental data generated by genome sequencing has provided an impetus for the development of automated methods for predicting the functions of proteins that have been deduced by sequence analysis and lack experimental characterization. Prediction of Protein Structures, Functions and Interactions presents a comprehensive overview of methods for prediction of protein structure or function, with the emphasis on their availability and possibilities for their combined use. Methods of modeling of individual proteins, prediction of their interactions, and docking of complexes are put in the context of predicting gene ontology (biological process, molecular function, and cellular component) and discussed in the light of their contribution to the emerging field of systems biology. Topics covered include: first steps of protein sequence analysis and structure prediction automated prediction of protein function from sequence template-based prediction of three-dimensional protein structures: fold-recognition and comparative modelling template-free prediction of three-dimensional protein structures quality assessment of protein models prediction of molecular interactions: from small ligands to large protein complexes macromolecular docking integrating prediction of structure, function, and interactions Prediction of Protein Structures, Functions and Interactions focuses on the methods that have performed well in CASPs, and which are constantly developed and maintained, and are freely available to academic researchers either as web servers or programs for local installation. It is an essential guide to the newest, best methods for prediction of protein structure and functions, for researchers and advanced students working in structural bioinformatics, protein chemistry, structural biology and drug discovery.

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Sriganesh Srihari Computational Prediction of Protein Complexes from Protein Interaction Networks


Complexes of physically interacting proteins constitute fundamental functional units that drive almost all biological processes within cells. A faithful reconstruction of the entire set of protein complexes (the «complexosome») is therefore important not only to understand the composition of complexes but also the higher level functional organization within cells. Advances over the last several years, particularly through the use of high-throughput proteomics techniques, have made it possible to map substantial fractions of protein interactions (the «interactomes») from model organisms including Arabidopsis thaliana (a flowering plant), Caenorhabditis elegans (a nematode), Drosophila melanogaster (fruit fly), and Saccharomyces cerevisiae (budding yeast). These interaction datasets have enabled systematic inquiry into the identification and study of protein complexes from organisms. Computational methods have played a significant role in this context, by contributing accurate, efficient, and exhaustive ways to analyze the enormous amounts of data. These methods have helped to compensate for some of the limitations in experimental datasets including the presence of biological and technical noise and the relative paucity of credible interactions. In this book, we systematically walk through computational methods devised to date (approximately between 2000 and 2016) for identifying protein complexes from the network of protein interactions (the protein-protein interaction (PPI) network). We present a detailed taxonomy of these methods, and comprehensively evaluate them for protein complex identification across a variety of scenarios including the absence of many true interactions and the presence of false-positive interactions (noise) in PPI networks. Based on this evaluation, we highlight challenges faced by the methods, for instance in identifying sparse, sub-, or small complexes and in discerning overlapping complexes, and reveal how a combination of strategies is necessary to accurately reconstruct the entire complexosome.

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Hugo Kubinyi Pharmacophores and Pharmacophore Searches


This handbook is the first to address the practical aspects of this novel method. It provides a complete overview of the field and progresses from general considerations to real life scenarios in drug discovery research. Starting with an introductory historical overview, the authors move on to discuss ligand-based approaches, including 3D pharmacophores and 4D QSAR, as well as the concept and application of pseudoreceptors. The next section on structure-based approaches includes pharmcophores from ligand-protein complexes, FLIP and 3D protein-ligand binding interactions. The whole is rounded off with a complete section devoted to applications and examples, including modeling of ADME properties. With its critical evaluation of pharmacophore-based strategies, this book represents a valuable aid for project leaders and decision-makers in the pharmaceutical industry, as well as pharmacologists, and medicinal and chemists.

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Giovanni Cesareni Modular Protein Domains


Since the full functionality of any given protein can only be understood in terms of its interaction with other, often regulatory proteins, this unique reference source covers all relevant protein domains, including SH2, SH3, PDZ, WW, PTB, EH, PH and PX. Its user-oriented concept combines broad coverage with easy retrieval of essential information, and includes a special section on Web-based tools and databases covering protein modules and functional peptide motifs. Essential for the study of protein-protein interactions in vivo or in silico, and a prerequisite for successful functional proteomics studies. With a prologue by Sir Tom Blundell.

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Hugo Kubinyi Protein-Ligand Interactions


The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution to the constant search for, e. g., improved enzyme inhibitors, and new concepts such as that of pharmacophores are being developed. An up-to-date presentation of an eternally young topic, this book is an indispensable information source for chemists, biochemists and pharmacologists dealing with the binding of ligands to proteins.

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Группа авторов Protein-Lipid Interactions


In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant hermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes. The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as well as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source for researchers in academia and industry.

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Kenneth Lipkowitz B. Reviews in Computational Chemistry


The Reviews in Computational Chemistry series brings together leading authorities in the field to teach the newcomer and update the expert on topics centered on molecular modeling, such as computer-assisted molecular design (CAMD), quantum chemistry, molecular mechanics and dynamics, and quantitative structure-activity relationships (QSAR). This volume, like those prior to it, features chapters by experts in various fields of computational chemistry. Topics in Volume 29 include: Noncovalent Interactions in Density-Functional Theory Long-Range Inter-Particle Interactions: Insights from Molecular Quantum Electrodynamics (QED) Theory Efficient Transition-State Modeling using Molecular Mechanics Force Fields for the Everyday Chemist Machine Learning in Materials Science: Recent Progress and Emerging Applications Discovering New Materials via a priori Crystal Structure Prediction Introduction to Maximally Localized Wannier Functions Methods for a Rapid and Automated Description of Proteins: Protein Structure, Protein Similarity, and Protein Folding

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Hugo Kubinyi – Wikipedia

Ab 1985 war er bei der BASF, bei der er 2001 pensioniert wurde. Ab 1987 war er dort für das Wirkstoffdesign, Molecular Modelling und Röntgenkristallographie von Proteinen zuständig und ab 1998 auch für Kombinatorische Chemie in den Biowissenschaften. Er forschte besonders über QSAR -Methoden und Struktur-Wirkungsbeziehungen.

Protein-Protein Interactions in Drug Discovery Methods and ...

Protein-Protein Interactions in Drug Discovery Methods and Principles in Medicinal Chemistry, Band 56: Amazon.de: Alexander Dömling, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers: Fremdsprachige Bücher

Protein Kinases as Drug Targets Methods and Principles in ...

Protein Kinases as Drug Targets (Methods and Principles in Medicinal Chemistry, Band 49) | Bert Klebl, Gerhard Müller, Michael Hamacher, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers | ISBN: 9783527317905 | Kostenloser Versand für alle Bücher mit Versand und Verkauf duch Amazon.

Hugo Kubinyi

Hugo Kubinyi, www.kubinyi.de modified ligands Chemical Genetics - Orthogonal Ligand-Protein Pairs for the Study of Signalling Pathways A. C. Bishop et al., Nature 407, 395-401 (2000) Hugo Kubinyi, www.kubinyi.de modified modified ligands kinases Chemical Genetics - Orthogonal Ligand-Protein Pairs for the Study of Signalling Pathways

Hugo Kubinyi, www.kubinyi.de Drug Design - Problems in ...

Hugo Kubinyi, www.kubinyi.de Annual and Cumulative Growth of the Protein Data Bank 76,706 X-ray structures (proteins: 71,626) 9,741 NMR structures (proteins: 8,529) 489 electron microsc. (proteins: 337) Date: January 02, 2013 Source: www.rscb.org/pdb/statistics Hugo Kubinyi, www.kubinyi.de Problems of Resolution of Protein 3D Structures

3D QSAR in drug design [electronic resource] : Kubinyi ...

3D QSAR in Drug Design: Ligand-Protein Interactions and Molecular Similarity Author: Hugo Kubinyi, Gerd Folkers, Yvonne C. Martin Published by Springer Netherlands ISBN: 978-0-7923-4790-3 DOI: 10.1007/0-306-46857-3 Table of Contents: Progress in Force-Field Calculations of Molecular Interaction Fields and Intermolecular Interactions

Hugo Kubinyi, Home Page

Hugo Kubinyi CURRICULUM DOWNLOAD of LECTURES BOOKS AND PUBLICATIONS PROGRAM BILIN Welcome ! Willkommen ! ADDRESS Prof. Dr. Hugo Kubinyi Donnersbergstrasse 9 D-67256 Weisenheim am Sand Germany E-mail [email protected] FAX +49-(0)6353-508233 ...

Structure-based design of enzyme inhibitors ... - kubinyi.de

4 Current Opinion in Drug Discovery and Development 1998 Vol 1 No 1 Structure-based design of enzyme inhibitors and receptor ligands Hugo Kubinyi Address Combinatorial Chemistry and Molecular Modelling ZHF/G - A30

Wiley: Protein-Protein Interactions in Drug Discovery ...

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields ...

Home | HUGO Gene Nomenclature Committee

The HGNC is a resource for approved human gene nomenclature containing ~42000 gene symbols and names and 1300+ gene families and sets

Protein-Ligand Interactions Methods and Principles in ...

Protein-Ligand Interactions (Methods and Principles in Medicinal Chemistry (53), Band 53) | Gohlke, Holger, Mannhold, Raimund, Kubinyi, Hugo, Folkers, Gerd | ISBN: 9783527329663 | Kostenloser Versand für alle Bücher mit Versand und Verkauf duch Amazon.

Protein Crystallography in Drug Discovery Methods and ...

Protein Crystallography in Drug Discovery Methods and Principles in Medicinal Chemistry, Band 20: Amazon.de: Robert E. Babine, Sherin S. Abdel-Meguid, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers: Fremdsprachige Bücher

3D QSAR in Drug Design - Ligand-Protein Interactions and ...

Ligand-Protein Interactions and Molecular Similarity. Editors: Kubinyi, Hugo, Folkers, Gerd, Martin, Yvonne C. (Eds.) Free Preview. Buy this book eBook 192,59 € price for Spain (gross) Buy eBook ISBN 978-0-306-46857-5; Digitally watermarked, DRM-free ...

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Editors: Kubinyi, Hugo, Folkers, Gerd, Martin, Yvonne C. (Eds.) Free Preview. Buy this book eBook 234,33 € ... Building a Bridge between G-Protein-Coupled Receptor Modelling, Protein Crystallography and 3D QSAR Studies for Ligand Design. Pages 233-255. Kim, Ki Hwan . Preview Buy Chapter 25,95 € A Critical Review of Recent CoMFA Applications. Pages 257-315. Kim, Ki Hwan (et al.) Preview Buy ...

Combinatorial and computational approaches in ... - kubinyi.de

16 Current Opinion in Drug Discovery and Development 1998 Vol 1 No 1 Combinatorial and computational approaches in structure-based drug design Hugo Kubinyi Address Combinatorial Chemistry and Molecular Modelling ZHF/G - A30

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Hugo Kubinyi, www.kubinyi

(ohne Proteine und Impfstoffe) (n = 877) Hugo Kubinyi, www.kubinyi.de N N Cl Cl O N N O N CH 3 Cl + + CH 3NH 2 Chlordiazepoxid--H N CH 3 HO N CH 3 Naftifin H+ Zufallsentdeckungen: Unerwartete Umlagerungen. Hugo Kubinyi, www.kubinyi.de Zufallsentdeckungen von Wirkstoffen Acetanilid, Acetylsalicylsäure, Aminoglutethimid, Amphetamin, Chloralhydrat, Chlordiazepoxid, Chlorpromazin, Cinnarizin ...

Hugo Kubinyi, www.kubinyi.de The Long Road from QSAR to ...

protein HCV polymerase 1, 2, 3 HIV protease HIV Reverse Influenza HRV coat HCV polymerase Transcriptase Neuraminidase protein 1, 2, 3 50 models 100 inhibitors. Hugo Kubinyi, www.kubinyi.de 1846 Models (195 Targets) Accelrys/ Scitegic ...

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Hugo Kubinyi Books – Biography and List of Works – Author of ‘3d Qsar In Drug Design’ Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. The ready reference opens with a general introd Significant progress has been made in the study of ...

Der Schlüssel zum Schloß II. Hansch‐Analyse, 3D‐QSAR und ...

Hugo Kubinyi, ZHB/W, A 30, BASF Aktiengesellschaft, D‐67056 LudwigshafenSearch for more papers by this author. Prof. Dr. Hugo Kubinyi . Corresponding Author. Wirkstoffdesign, BASF AG, 67056 Ludwigshafen. Hugo Kubinyi, geb. 1940 in Wien/Österreich, Studium der Chemie an der Universität Wien und am Max Planck‐Institut für Biochemie in München, von 1965 bis 1966 Postdoc‐Zeit am ...

3D QSAR in Drug Design - Volume 2: Ligand-Protein ...

Editors: Kubinyi, Hugo, Folkers, Gerd, Martin, Yvonne C. (Eds.) Buy this book Special Cover Type 307,84 € price for Spain (gross) ... Volume 2 (Ligand-Protein Interactions and Molecular Similarity) divides into three sections dealing with Ligand-Protein Interactions, Quantum Chemical Models and Molecular Dynamics Simulations, and Pharmacophore Modelling and Molecular Similarity, respectively ...

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Wirkstoffdesign | SpringerLink

Dieses von Hans-Joachim Böhm, Gerhard Klebe und Hugo Kubinyi begründete Lehrbuch richtet sich an Studenten der Pharmazie, Chemie und Biowissenschaften, aber auch an Quereinsteiger in Forschungs- und Entwicklungsabteilungen der Pharmazeutischen Industrie. Es wurde in der 1. Auflage mit dem Literaturpreis des Fonds der Chemischen Industrie ausgezeichnet, weil es sich "konzeptionell sehr stark ...

3D Qsar in Drug Design Volume 2 Ligand-Protein ...

3D Qsar in Drug Design Volume 2 Ligand-Protein Interactions and Molecular Simi - Volumes 2 and 3 of the 3D QSAR in Drug Design series aim to review the progress being made in CoMFA and other 3D QSAR (EAN:9780792347927) auf Unifachbuch.de.de

Protein-Ligand Interactions: 53: Gohlke, Holger, Mannhold ...

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Ligand Design for G Protein-coupled Receptors Methods and ...

Ligand Design for G Protein-coupled Receptors (Methods and Principles in Medicinal Chemistry, Band 30) | Rognan, Didier, Mannhold, Raimund, Kubinyi, Hugo, Folkers, Gerd | ISBN: 9783527312849 | Kostenloser Versand für alle Bücher mit Versand und Verkauf duch Amazon.

Hugo Kubinyi's research works | Friedrich-Alexander ...

Hugo Kubinyi is a medicinal chemist with 35 years of industrial experience, at KNOLL AG and BASF AG, Ludwigshafen, Germany. Since 1987, until his retirement in summer 2001, he was responsible for...

Protein Kinases as Drug Targets by Bert Klebl, Gerhard ...

Protein Kinases as Drug Targets - Ebook written by Bert Klebl, Gerhard Müller, Michael Hamacher, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers. Read this book using Google Play Books app on your PC, android, iOS devices. Download for offline reading, highlight, bookmark or take notes while you read Protein Kinases as Drug Targets.

Protein-Ligand Interactions - ISBN: 9783527645978 - (ebook ...

Protein-Ligand Interactions - ISBN: 9783527645978 - (ebook) - von Holger Gohlke, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers, Verlag: Wiley-VCH

CHANGING PARADIGMS IN DRUG DISCOVERY HUGO KUBINYI

E-Mail: [email protected] Received: 5th May 2004 / Published: 22nd July 2005 ABSTRACT The strategies of drug design have ch anged significantly within the past few decades. Whereas chemistry, biological activity hypotheses and animal experiments dominated drug research, especially in its "golden age", from the sixties to the eighties of the last century, many new technologies have developed ...

Protein Therapeutics: Feger, Georg, Bernard, Alain, Wells ...

Protein Therapeutics: Feger, Georg, Bernard, Alain, Wells, Timothy, Mannhold, Raimund, Kubinyi, Hugo, Folkers, Gerd: Amazon.com.au: Books

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Protein-ligand Interactions: From Molecular Recognition to Drug Design (Methods and Principles in Medicinal Chemistry) Wiley VCH. Hans-Joachim Bohm, Gisbert Schneider, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers. Year: 2003. Language: english. File: PDF, 3.49 MB. 3. Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability (Methods and Principles in ...

HUGO KUBINYI PDF - magmar.eu

Böcker av Hugo Kubinyi. Edited by a former coworker of W thrich, this book presents the theoretical background on NMR of biomolec Chapter authors from leading phar Volume 2 Ligand-Protein Interaction Planetary Atmospheric Electricity Francois Leblanc.

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Hugo Kubinyi The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis. A new chapter on screening complements the overview of combinatorial strategy and synthetic methods.

Wiley: Search Results

by Friedlieb Pfannkuch (Editor), Laura Suter-Dick (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor) January 2015, Hardcover (E-book also available) US $195.00 Buy. In vivo Models for Drug Discovery, Volume 62. by Jose M Vela (Editor), Rafael Maldonado (Editor), Michel Hamon (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series ...

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Protein Kinases as Drug Targets, Volume 49 1st Edition by Bert Klebl (Editor), Gerhard Müller (Editor), Michael Hamacher (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor) & 3 more

Download e-book for kindle: Ligand Design for G Protein ...

By Didier Rognan, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers. ISBN-10: 3527312846. ISBN-13: 9783527312849. Content material: G protein-coupled receptors within the human genome / Robert Fredriksson and Helgi B. Schiöth -- Why G protein-coupled receptors databases are wanted / Jacques Haiech ...

Hans-Joachim Böhm / Gerhard / Hugo Kubinyi

Hans-Joachim Böhm / Gerhard Klebe / Hugo Kubinyi Wirkstoffdesign Der Weg zum Arzneimittel. Geleitwort VII Vorwort der Autoren und Danksagung IX Einführung 1 Teil I Grundlagen der Arzneimittelforschung 7 1 Arzneimittelforschung gestern, heute, morgen 9 2 Am Anfang stand der glückliche Zufall 3 1 3 Klassische Arzneimittelforschung 45 4 Wie wirkt ein Arzneimittel? 7 3 5 Protein-Ligand ...

Suchergebnisse - Wiley-VCH eBooks

Microwaves in Organic and Medicinal Chemistry von: C. Oliver Kappe, Alexander Stadler, Doris Dallinger, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

Protein Crystallography in Drug Discovery: Babine, Robert ...

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Wiley: Pharmacokinetics and Metabolism in Drug Design, 3rd ...

Douglas A. Smith, Charlotte Allerton, Hugo Kubinyi, Han Walker, Don K. Walker, Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor) ISBN: 978-3-527-32954-0 268 pages

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Pris: 1589 kr. E-bok, 2012. Laddas ned direkt. Köp Protein-Ligand Interactions av Gohlke Holger Gohlke, Mannhold Raimund Mannhold, Kubinyi Hugo Kubinyi, Folkers Gerd Folkers på Bokus.com.

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Hugo Kubinyi - Böcker | Bokus bokhandel

av Wanner Klaus Wanner, H Fner Georg H Fner, Mannhold Raimund Mannhold, Kubinyi Hugo Kubinyi, Folkers Gerd Folkers E-bok , Engelska, 2007-06-27 2349

Группа авторов Protein Analysis using Mass Spectrometry


Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis

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Vladimir Uversky Protein Oxidation and Aging


Reviews our current understanding of the role of protein oxidation in aging and age-related diseases Protein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently by exploring the aging process and developing more effective therapies to prevent or treat age-related diseases. There have been many studies dedicated to the relationship between protein oxidation and age-related pathology; now it is possible for researchers and readers to learn new techniques as utilizing protein oxidation products as biomarkers for aging. Protein Oxidation and Aging begins with a description of the tremendous variety of protein oxidation products. Furthermore, it covers: Major aspects of the protein oxidation process Cellular mechanisms for managing oxidized proteins Role of protein oxidation in aging Influence of genetic and environmental factors on protein oxidation Measuring protein oxidation in the aging process Protein oxidation in age-related diseases References at the end of each chapter serve as a gateway to the growing body of original research studies and reviews in the field.

15874.13 RUR

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Hugo Kubinyi Protein Crystallography in Drug Discovery


The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.

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Группа авторов Protein Structure Determination


Presents methods for determining the secondary and tertiary structure of proteins. The issues covered here involve theoretical/empirical approaches for predicting protein structure; a review using protein ligand interactions to study surface properties of proteins; use of fluorescence techniques to study structure and dynamics of proteins; and limited proteolysis with monoclonal antibodies to understand how specific structural features confer biological function.

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Kate Widdows Protein Conformation


How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in the fields of NMR spectroscopy, X-ray crystallography, protein engineering and molecular modeling offer provocative insights into current views on the protein folding problem and various aspects for future progress.

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Joaquim Ros Protein Carbonylation. Principles, Analysis, and Biological Implications


Protein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman’s lab at NIH started in early 1980s. Since then, detecting protein carbonyls in oxidative stress situations became a highly efficient tool to uncover biomarkers of oxidative damage in normal and altered cell physiology. In this book, research groups from several areas of interest have contributed to update the knowledge regarding detection, analyses and identification of carbonylated proteins and the sites where these modifications occur. The scientific community will benefit from these reviews since they deal with specific, detailed technical approaches to study formation and detection of protein carbonyls. Moreover, the biological impact of such modifications in metabolic, physiologic and structural functions and, how these alterations can help understanding the downstream effects on cell function are discussed. Oxidative stress occurs in all living organisms and affects proteins and other macromolecules: Protein carbonylation is a measure of oxidative stress in biological systems Mass spectrometry, fluorescent labelling, antibody based detection, biotinylated protein selection and other methods for detecting protein carbonyls and modification sites in proteins are described Aging, neurodegenerative diseases, obstructive pulmonary diseases, malaria, cigarette smoke, adipose tissue and its relationship with protein carbonylation Direct oxidation, glycoxidation and modifications by lipid peroxidation products as protein carbonylation pathways Emerging methods for characterizing carbonylated protein networks and affected metabolic pathways

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Martin Rechsteiner Protein Degradation


The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation. Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

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Группа авторов Protein Aggregation in Bacteria


Focuses on the aggregation of recombinant proteins in bacterial cells in the form of inclusion bodies—and on their use in biotechnological and medical applications The first book devoted specifically to the topic of aggregation in bacteria, Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells provides a large overview of protein folding and aggregation, including cell biology and methodological aspects. It summarizes, for the first time in one book, ideas and technical approaches that pave the way for a direct use of inclusion bodies in biotechnological and medical applications. Protein Aggregation in Bacteria covers: Molecular and cellular mechanisms of protein folding, aggregation, and disaggregation in bacteria Physiological importance and consequences of aggregation for the bacterial cell Factors inherent to the protein sequence responsible for aggregation and evolutionary mechanisms to keep proteins soluble Structural properties of proteins expressed as soluble aggregates and as inclusion bodies within bacterial cells both from a methodological point of view and with regard to their similarity with amyloids Control of the structural and functional properties of aggregated proteins and use thereof in biotechnology and medicine Protein Aggregation in Bacteria is ideal for researchers in protein science, biochemistry, bioengineering, biophysics, microbiology, medicine, and biotechnology, particularly if they are related with the production of recombinant proteins and pharmaceutical science.

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Dev Kambhampati Protein Microarray Technology


This book is the first of its kind in the field of protein microarrays and addresses novel strategies for constructing highly functional and biocompatible microarrays for screening proteins. The list of authors consisting of world leading experts provide a roadmap for solving the complex challenges that are currently faced while monitoring protein-protein interactions over a wide range of microarray platforms. In doing so, they also offer a comprehensive overview of microarray surface chemistry, detection technologies, fabrication options for array development, and data analysis of numerous types of protein interactions. Topics covered include: -Types of biomolecular interactions -Surface chemistry -Detection technologies -Spotting technologies -Bioinformatics/data analysis. While primarily intended to serve as a reference for researchers and students embarking on the exciting fields of proteomics, drug discovery and clinical diagnostics, this technology is also expected to potentially impact the areas of food diagnostics, environmental monitoring and national security.

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Ueno Takafumi Coordination Chemistry in Protein Cages. Principles, Design, and Applications


Sets the stage for the design and application of new protein cages Featuring contributions from a team of international experts in the coordination chemistry of biological systems, this book enables readers to understand and take advantage of the fascinating internal molecular environment of protein cages. With the aid of modern organic and polymer techniques, the authors explain step by step how to design and construct a variety of protein cages. Moreover, the authors describe current applications of protein cages, setting the foundation for the development of new applications in biology, nanotechnology, synthetic chemistry, and other disciplines. Based on a thorough review of the literature as well as the authors' own laboratory experience, Coordination Chemistry in Protein Cages Sets forth the principles of coordination reactions in natural protein cages Details the fundamental design of coordination sites of small artificial metalloproteins as the basis for protein cage design Describes the supramolecular design and assembly of protein cages for or by metal coordination Examines the latest applications of protein cages in biology and nanotechnology Describes the principles of coordination chemistry that govern self-assembly of synthetic cage-like molecules Chapters are filled with detailed figures to help readers understand the complex structure, design, and application of protein cages. Extensive references at the end of each chapter serve as a gateway to important original research studies and reviews in the field. With its detailed review of basic principles, design, and applications, Coordination Chemistry in Protein Cages is recommended for investigators working in biological inorganic chemistry, biological organic chemistry, and nanoscience.

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