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Hugo Kubinyi Voltage-Gated Ion Channels as Drug Targets


Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.

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Valentin Gribkoff K. Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels


This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.

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Группа авторов Pumps, Channels and Transporters


Describes experimental methods for investigating the function of pumps, channels and transporters Covers new emerging analytical methods used to study ion transport membrane proteins such as single-molecule spectroscopy Details a wide range of electrophysiological techniques and spectroscopic methods used to analyze the function of ion channels, ion pumps and transporters Covers state-of-the art analytical methods to study ion pumps, channels, and transporters, and where analytical chemistry can make further contributions

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Levitan Irena Cholesterol Regulation of Ion Channels and Receptors


Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health Drawing together and analyzing all the latest research findings, this book explores the role of cholesterol in the regulation of ion channels and receptors, including its pathological effects. It is the first book to comprehensively describe the complex mechanisms by which cholesterol regulates two major classes of membrane proteins. Moreover, it sheds new light on how cholesterol affects essential cellular functions such as the contraction of the heart, propagation of nerve impulses, and regulation of blood pressure and kidney function. Written and edited by leading pioneers in the field, Cholesterol Regulation of Ion Channels and Receptors is divided into three parts: Part I, Cholesterol Regulation of Membrane Properties, introduces the heterogeneity of cholesterol distribution in biological membranes and the physical and biological implications of the formation of cholesterol-rich membrane domains. Part II, Cholesterol Regulation of Ion Channels, examines the mechanisms underlying cholesterol sensitivities of ion channels, including the regulation of ion channels by cholesterol as a boundary lipid. Part III, Cholesterol Regulation of Receptors, explores the latest discoveries concerning how cholesterol regulates distinct types of receptors, including G-protein coupled receptors, LDL and scavenger receptors, and innate immune system receptors. Increased levels of cholesterol represent a major health risk. Understanding cholesterol regulation of ion channels and receptors is essential for facilitating the development of new therapeutic strategies to alleviate the impact of pathological cholesterol conditions. With this book as their guide, readers have access to the most current knowledge in the field.

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Hugo Kubinyi Nuclear Receptors as Drug Targets


Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.

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Gail Cardew Gramicidin and Related Ion Channel-Forming Peptides


Gramicidin channels have been studied intensively for more than 25 years. They serve as model transport systems for large protein ion channels, since it is difficult to glean high-resolution structural information on the latter. This book includes contributions from virtually all the major scientists studying gramicidin channels and is the only compilation of work in this field. It discusses crystallographic, spectroscopic, electrophysiological and computational studies, especially in the light of the recent availability of high-resolution structural data, and it compares these with insights derived from larger systems. As well as drawing together much new and exciting work in this field, it provides pointers to promising new research directions.

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Paperless Recorder Industrial Grade Multiple Channels Data Temperature Humidity Current Voltage and Pressure Curve Temperat

Hugo Kubinyi High-Throughput Screening in Drug Discovery


Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results. For both academics and professionals in the pharma and biotech industries working on small molecule screening.

23483.69 RUR

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3pcs RobotDyn TP4056 Li-Ion Battery Charger Module with Protection Constant Current Constant Voltage


3pcs RobotDyn TP4056 Li-Ion Battery Charger Module with Protection Constant Current Constant Voltage

611.64 RUR
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Derek Trezise J. Expression and Analysis of Recombinant Ion Channels


Filling the gap created over the past five years, during which many new techniques have entered the market, this book is directed at both the new and the experienced ion channel researcher wishing to learn more about the considerations and methods for studying recombinant ion channels. These latest developments are covered here for the first time, contributed by editors and authors working for major pharmaceutical companies and who routinely apply these techniques in their daily work. The first three chapters cover the use of the Xenopus oocyte expression system for structure-function studies, from basic approaches for manipulating ion channel cDNAs to more specialized but powerful techniques. This is followed by reviews of strategies and methodologies available for expressing channels in mammalian cells and for their analysis by patch-clamp electrophysiology. Chapters 6 to 8 review the latest methodologies for ion channel drug discovery, including high throughput screening using fluorescence and luminescence, as well as automated planar array electrophysiology. The remaining two chapters focus on approaches for determining ion channel crystal structures and on computational approaches to understanding channel mechanisms at atomic resolution. Rather than provide detailed protocols, indicated by references in each chapter, the authors provide a comprehensive and easily accessible overview of the techniques involved, reviewing underlying principles and providing working guidelines as well as an understanding of the key theoretical and practical considerations associated with each topic. In each case, this practical advice is illustrated by real life examples, taken either from the author's own experience or from key examples in the literature, providing valuable practical hints not found elsewhere. The result is a compendium of practical ion channel information that will prove a valuable resource to academic and industrial workers alike.

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Hugo Kubinyi, Home Page

Hugo Kubinyi CURRICULUM DOWNLOAD of LECTURES BOOKS AND PUBLICATIONS PROGRAM BILIN Welcome ! Willkommen ! ADDRESS Prof. Dr. Hugo Kubinyi Donnersbergstrasse 9 D-67256 Weisenheim am Sand Germany E-mail [email protected] FAX +49-(0)6353-508233 ...

Hugo Kubinyi – Wikipedia

Ab 1985 war er bei der BASF, bei der er 2001 pensioniert wurde. Ab 1987 war er dort für das Wirkstoffdesign, Molecular Modelling und Röntgenkristallographie von Proteinen zuständig und ab 1998 auch für Kombinatorische Chemie in den Biowissenschaften. Er forschte besonders über QSAR -Methoden und Struktur-Wirkungsbeziehungen.

Voltage-Gated Ion Channels as Drug Targets Methods and ...

Voltage-Gated Ion Channels as Drug Targets (Methods and Principles in Medicinal Chemistry, Band 29) | David J. Triggle, Murali Gopalakrishnan, David Rampe, Wei Zheng, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers | ISBN: 9783527312580 | Kostenloser Versand für alle Bücher mit Versand und Verkauf duch Amazon.

Hugo Kubinyi, Home Page

Prof. Dr. Hugo Kubinyi Donnersbergstrasse 9 67256 Weisenheim am Sand Deutschland E-mail [email protected] FAX 06353-508233 Letztes Update: 22. Oktober 2016 ...

Voltage-Gated Ion Channels as Drug Targets: David J ...

Voltage-Gated Ion Channels as Drug Targets [David J. Triggle, Murali Gopalakrishnan, David Rampe, Wei Zheng, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers] on Amazon.com. *FREE* shipping on qualifying offers. Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular ...

Hugo Kubinyi, www.kubinyi

Hugo Kubinyi, www.kubinyi.de Kriterien für eine „gute“ Leitstruktur (Schering) Molgewicht 200 bis 500 Log P / Log D -1 bis 5 Donorgruppen 0 bis 5 Akzeptorgruppen < 10 Löslichkeit in Wasser 5 mg L-1 (oder 10 x IC 50) biol. Aktivität 100 nM – 1 mM aktiv in zellulärem Testsystem Selektivität > 10-fach (abhängig von Target) ausreichende Permeabilität in CaCo-Zellen Stabilität in ...

kubinyi hugo - ZVAB

Isolierung, Struktur und Partialsynthese biologisch aktiver Naturstoffe aus Crotonöl. Dissertation. von Kubinyi, Hugo und eine große Auswahl ähnlicher Bücher, Kunst und Sammlerstücke erhältlich auf ZVAB.com.

Hugo Kubinyi, Lectures

Lectures of the Drug Design Course (download of PDF's) *) *) to avoid copyright conflicts, these files are for educational purposes only; other use of the material or its parts is therefore prohibited.

hugo kubinyi – genius – kubinyi lectures | LinkedIn

Sehen Sie sich das Profil von hugo kubinyi auf LinkedIn an, dem weltweit größten beruflichen Netzwerk. 1 Job ist im Profil von hugo kubinyi aufgelistet. Sehen Sie sich auf LinkedIn das vollständige Profil an. Erfahren Sie mehr über die Kontakte von hugo kubinyi und über Jobs bei ähnlichen Unternehmen.

Hugo Kubinyi, Virtual Screening. Principles, Challenges ...

In LitRes digital library you can download the book Virtual Screening. Principles, Challenges, and Practical Guidelines by Hugo Kubinyi! Read reviews of the book and write your own at LitRes!

Hugo Kubinyi

Hugo Kubinyi, www.kubinyi.de Activities of Benzodiazepines N N Me O Cl F N N N COOEt O Me N N N COOEt Cl O Me N N Me F N H O S C. Wermuth, The Practice of Medicinal Chemistry, 1996, p. 548; D. Römer et al., Nature 298, 759-760 (1982) diazepam (agonist) positive intrinsic activity at the GABAA receptor (tranquilizer) flumazenil (antagonist) no intrinsic activity at the GABAA receptor (antidot ...

Voltage-Gated Ion Channels as Drug Targets: Triggle, David ...

Voltage-Gated Ion Channels as Drug Targets: Triggle, David J., Gopalakrishnan, Murali, Rampe, David, Zheng, Wei, Mannhold, Raimund, Kubinyi, Hugo, Folkers, Gerd ...

3D QSAR in Drug Design - Recent Advances | Hugo Kubinyi ...

Significant progress has been made in the study of three-dimensional quantitative structure-activity relationships (3D QSAR) since the first publication by Richard Cramer in 1988 and the first volume in the series, 3D QSAR in Drug Design. Theory, Methods and Applications, published in 1993. The aim

Pharmacophore Analyses - Hugo Kubinyi, Home Page

Hugo Kubinyi, www.kubinyi.de Pharmacophore Analyses Hugo Kubinyi Germany E-Mail [email protected] HomePage www.kubinyi.de Hugo Kubinyi, www.kubinyi.de Similarity and Dissimilarity 2D similarity based on groups + connectivity e.g., Daylight fingerprints or MDL keys 2D similarity = Tanimoto index 0 <= Tanimoto Index (i, j) <= 1 e.g. (example): T(A,B) = 5 / 9 = 0.555 # bits set in A and B ...

Bioisosterie – Wikipedia

Bioisosterie ist ein Begriff aus der medizinischen Chemie. Zwei Moleküle werden als bioisoster bezeichnet, wenn sie eine biologisch vergleichbare Wirkung in vivo (also im lebenden System) zeigen und isoster sind. Ein Beispiel wären die Opiate, bei denen die meisten untereinander bioisoster sind, da sie fast dieselbe biologische Wirkung haben.. Der Begriff wird insbesondere im Zusammenhang ...

Hugo Kubinyi | Open Library

by Hugo Kubinyi, Gerd Folkers, Yvonne Connolly Martin. First published in 1899 2 editions — 1 previewable Not in Library. Download for print-disabled Molecular drug properties by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers, Raimund Mannhold. First published in 2007 2 editions — 2 previewable Check Availability ...

3D QSAR in Drug Design - Volume 1: Theory Methods and ...

Editors: Kubinyi, Hugo (Ed.) Buy this book Hardcover 571,99 € price for Spain (gross) Buy Hardcover ISBN 978-90-72199-14-0; Free shipping for individuals worldwide ; Immediate ebook access, if available*, with your print order; Usually ready to be dispatched within 3 to 5 business days. ...

Hugo Kubinyi - Info zur Person mit Bilder, News & Links ...

117 Ergebnisse zu Hugo Kubinyi: Weisenheim, kostenlose Person-Info bei Personsuche Yasni.de, alle Infos zum Namen im Internet

Free Wilson Analysis. Theory, Applications and its ...

Hugo Kubinyi, 2D QSAR Models, Computational Medicinal Chemistry for Drug Discovery, 10.1201/9780203913390, (2003). Crossref. Lucjan Strekowski, Jerzy L. Mokrosz, W. David Wilson, Maria J. Mokrosz, Alewtina Strekowski, Stereoelectronic factors in the interaction with DNA of small aromatic molecules substituted with a short cationic chain : Importance of the polarity of the aromatic system of ...

QSAR: Hansch Analysis and Related Approaches

Kubinyi, Hugo: QSAR: Hansch analysis and related approaches / by Hugo Kubinyi. - Weinheim- ; New York Basil ; Cambridge ; Tokyo : VCH, 1993 (Methods and principles in medicinal chemistry ; Vol. I) ISBN 3-527-30035-X (Weinheim . . .) ISBN 1-56081-768-2 (New York) NE: GT OVCH Verlagsgesellschaft mbH, D-69451 Weinheirn (Federal Republic of Germany), 1993 Printed on acid-free and chlorine-free ...

QSAR, QSAR: Hansch Analysis and Related Approaches - Hugo ...

Finding the new remedy for a certain disease: an inspired goal. QSAR, an invaluable tool in drug design, aids scientists to attain this aim.This book is a long-awaited comprehensive text to QSAR and related approaches. It provides a practice-oriented introduction to the theory, methods and analyses for QSAR relationships, including modelling-based and 3D approaches.Hugo Kubinyi is a leading ...

Hugo Kubinyi - Deutsche Digitale Bibliothek

Hugo Kubinyi. Link auf diese Seite. Hinweis zum Datenschutz Mit Klick auf "Einverstanden" können Sie diese Seite in sozialen Netzwerken weiterempfehlen. Dabei besteht die Möglichkeit, dass Daten von Ihrem Computer zum jeweiligen Anbieter sowie Daten des Anbieters auf Ihren Computer übertragen werden. Diese Zustimmung wird von Ihnen für 24 Stunden erteilt. Sie können die Zustimmung aber ...

HUGO KUBINYI PDF - mansic.eu

Hugo Kubinyi Books – Biography and List of Works – Author of ‘3d Qsar In Drug Design’ Chemoinformatics experts from large pharmaceutical companies, as well as from chemoinformatics service providers and from academia demonstrat Table of contents Volume 2: The basic aspects of ligand-protein interaction may be summarized under the term ‘molec Yet only with the recent elucidation of ...

Wirkstoffdesign. Der Weg zum Arzneimittel von Hans‐Joachim ...

Wirkstoffdesign. Der Weg zum Arzneimittel von Hans‐Joachim Böhm, Gerhard Klebe und Hugo Kubinyi, spektrum Akademischer Verlag, Heidelberg, Berlin, Oxford 1996, 599 S., zahlreiche farbige Abb. und mehrfarbige Strukturformelbilder, DM 98,‐, ISBN 3‐8274‐0012‐0

Wiley: Search Results

by Friedlieb Pfannkuch (Editor), Laura Suter-Dick (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor) January 2015, Hardcover (E-book also available) US $195.00 Buy. In vivo Models for Drug Discovery, Volume 62. by Jose M Vela (Editor), Rafael Maldonado (Editor), Michel Hamon (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series ...

QSAR, QSAR: Hansch Analysis and Related Approaches - Hugo ...

Hugo Kubinyi is a leading expert in QSAR. Readers will benefit from the author's 20 years of practical experience, from his careful calculations and recalculations of thousands of QSAR equations. Among the topics covered are: - physiocochemical parameters - quantitative models - statistical methods - Hansch analysis - Free Wilson analysis - 3D-QSAR approaches The book can readily be used as a ...

Chord Hugo 2 Review - Headfonics

However, comparing the voltage line out of the Hugo 2 to some of its competitors and even some desktop units you can see that the Hugo 2’s line out Vrms is the same as the Mojo at 3Vrms. Adjusting and Matching. Desktop units such as the Oppo Sonica DAC, Cayin iDAC-6, CDM and DAC-1 from NuPrime all float in-between 2Vrms and 2.4Vrms so this is actually a touch higher than the norm. You can ...

Wirkstoffdesign - Der Weg zum Arzneimittel von Hans ...

Hans-Joachim Böhm / Gerhard Klebe / Hugo Kubinyi Wirkstoffdesign - Der Weg zum Arzneimittel. Buch. Jetzt bewerten Jetzt bewerten. Merkliste; Auf die Merkliste; Bewerten Bewerten; Teilen Produkt teilen Produkterinnerung Produkterinnerung Produktdetails. Verlag: Spektrum Akademischer Verlag; ISBN-13: 9783827400123 ; ISBN-10: 3827400120; Artikelnr.: 25094960; Kundenbewertungen. Schreiben Sie ...

Qsar: Hansch Analysis and Related Approaches: Kubinyi ...

Qsar: Hansch Analysis and Related Approaches: Kubinyi, Hugo, Mannhold, Raimund, Krogsgaard–Larsen, Povl, Timmerman, Hendrik: Amazon.com.au: Books

Hugo Kubinyi | Book Depository

Discover Book Depository's huge selection of Hugo Kubinyi books online. Free delivery worldwide on over 20 million titles.

Hans-Joachim Böhm – Wikipedia

Hans-Joachim Böhm (* 20.November 1956 in Frankfurt am Main) ist ein deutscher Chemiker (Wirkstoffdesign).. Böhm studierte Chemie an der Universität Karlsruhe, an der er 1984 in Theoretischer Chemie promoviert wurde und sich 1993 habilitierte.Ab 1985 war er bei der Siemens AG in der Mikroelektronikforschung und ab 1988 bei BASF in Ludwigshafen. 1996 ging er zu Hoffmann-La Roche in Basel und ...

Hugo Kubinyi (Author of Wirkstoffdesign)

Hugo Kubinyi is the author of 3D Qsar in Drug Design (0.0 avg rating, 0 ratings, 0 reviews, published 1997), 3D QSAR in Drug Design (0.0 avg rating, 0 ra...

Hugo Kubinyi · OverDrive: ebooks, audiobooks, and videos ...

Hugo Kubinyi studied chemistry in Vienna, Austria. He earned his PhD and continued as a PostDoc at the German Cancer Research Centre in Heidelberg. In 1986 he was appointed as associate Professor of Pharmaceutical Chemistry at the University of He...

Chemical Similarity and Biological Activities

Hugo Kubinyi, www.kubinyi.de S MW = 78.11 mp. = 5.5°C bp. = 80.15°C Log P = 2.13 MR = 26.4 d = 0.879 MW = 84.14 mp. = -38°C bp. = 84°C Log P = 1.81 MR = 25.0 d = 1.057 1825, Michael Faraday "bicarburet of hydrogen", Fp. 42°F = 5.5°C 1879, Adolf v. Baeyer, Indigblau reaction 1882, Victor Meyer and Traugott Sandmeyer Discovery of thiophene The Serendipitous Discovery of Thiophene Hugo ...

Wiley: Chemoinformatics in Drug Discovery, Volume 23 ...

Tudor I. Oprea (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor) ISBN: 978-3-527-60420-3. 515 pages. March 2006. Description. This handbook provides the first-ever inside view of today's integrated approach to rational drug design. Chemoinformatics experts from large pharmaceutical companies, as well as from chemoinformatics service ...

Hochdurchsatz-Screening – Wikipedia

High-Throughput-Screening (HTS), auch Hochdurchsatz-Screening genannt, ist eine vor allem in der Pharmaforschung angewendete, automatisierte Methode, bei der im Hochdurchsatz an Zehntausenden bis Millionen von Substanzen biochemische, genetische oder pharmakologische Tests durchgeführt werden. Werden mehr als 100.000 Stoffe pro Tag untersucht, spricht man auch vom Ultra-High-Throughput ...

Thermodynamics and Kinetics of Drug Binding Methods and ...

Thermodynamics and Kinetics of Drug Binding Methods and Principles in Medicinal Chemistry, Band 65: Amazon.de: György M. Keserü, David Swinney, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers: Fremdsprachige Bücher

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Hugo Kubinyi | Book Depository

Descubre el gran catálogo de Hugo Kubinyi libros en línea. Envío gratis en todo el mundo en más de 20 millones de títulos.

Wikipedia – Die freie Enzyklopädie

Wikipedia ist ein Projekt zum Aufbau einer Enzyklopädie aus freien Inhalten, zu denen du sehr gern beitragen kannst.Seit März 2001 sind 2.493.953 Artikel in deutscher Sprache entstanden.. Geographie Geschichte Gesellschaft Kunst und Kultur Religion Sport Technik Wissenschaft; Artikel nach Themen; Artikel nach Kategorien

Suchergebnisse - Wiley-VCH eBooks

Microwaves in Organic and Medicinal Chemistry von: C. Oliver Kappe, Alexander Stadler, Doris Dallinger, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

Wirkstoffdesign (German Edition): Böhm, Hans-Joachim ...

Hugo Kubinyi arbeitet im Wirkstoffdesign des Hauptlaboratoriums der BASF AG. Er ist Vorsitzender der internationalen QSAR and Modelling Society und Herausgeber mehrerer Monographien und einer Buchreihe über Medizinische Chemie. Sein Spezialgebiet sind Struktur-Wirkungsbeziehungen und QSAR-Methoden. Product details . Paperback: 599 pages; Publisher: Spektrum Akademischer Verlag; 1 edition ...

Hohe Auszeichnung für Professor Dr. Hugo Kubinyi

Univ.-Prof. Dr. Hugo Kubinyi: Professor Kubinyi studierte in Wien, trat nach dem Studium als medizinischer Chemiker in die KNOLL AG Ludwigshafen ein, entwickelte ein teilsynthetisches Herzglykosid (Meproscillarin, 1978 in die Therapie eingeführt). Von 1987 – 2001 war Kubinyi bei BASF verantwortlich für das Molecular Modelling, die Proteinkristallographie und das Wirkstoffdesign, ab 1998 ...

Hunyadi János – Wikipédia

– Kubinyi András: Mátyás király. Vince kiadó, 2001. Tudomány – Egyetem sorozat A Szilágyi Sándor által szerkesztett, a millennium alkalmából megjelent tíz kötetes A magyar nemzet története című műben Schönherr Gyula így ír származásáról: „ Hunyadi János annak a délszlávból meghonosodott társadalomnak a szülötte, mely a török terjeszkedése elől ...

The Evolution of Drug Discovery: From Traditional ...

The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs | Ravina, Enrique, Kubinyi, Hugo | ISBN: 9783527326693 | Kostenloser Versand für alle Bücher mit Versand und Verkauf duch Amazon.

Hans-Joachim Böhm / Gerhard / Hugo Kubinyi

Hans-Joachim Böhm / Gerhard Klebe / Hugo Kubinyi Wirkstoffdesign Der Weg zum Arzneimittel. Geleitwort VII Vorwort der Autoren und Danksagung IX Einführung 1 Teil I Grundlagen der Arzneimittelforschung 7 1 Arzneimittelforschung gestern, heute, morgen 9 2 Am Anfang stand der glückliche Zufall 3 1 3 Klassische Arzneimittelforschung 45 4 Wie wirkt ein Arzneimittel? 7 3 5 Protein-Ligand ...

Suchergebnisse - AQUENSIS eBooks

Microwaves in Organic and Medicinal Chemistry von: C. Oliver Kappe, Alexander Stadler, Doris Dallinger, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

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Hugo Kubinyi Molecular Biology in Medicinal Chemistry


This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods. With its examination of these novel methods and generous practical advice, this is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.

23208.49 RUR

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Hugo Kubinyi Molecular Modeling


Written by experienced experts in molecular modeling, this books describes the basics to the extent that is necessary if one wants to be able to reliably judge the results from molecular modeling calculations. Its main objective is the description of the various pitfalls to be avoided. Without unnecessary overhead it leads the reader from simple calculations on small molecules to the modeling of proteins and other relevant biomolecules. A textbook for beginners as well as an invaluable reference for all those dealing with molecular modeling in their daily work!

16970.63 RUR

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